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federal_register: 2024-26682

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document_number title type abstract publication_date pub_year pub_month html_url pdf_url agency_names agency_ids excerpts
2024-26682 Nonclinical Safety Assessment of Oligonucleotide-Based Therapeutics; Draft Guidance for Industry; Availability Notice The Food and Drug Administration (FDA or Agency) is announcing the availability of a draft guidance for industry entitled "Nonclinical Safety Assessment of Oligonucleotide-Based Therapeutics." FDA is publishing this draft guidance which, when finalized, will provide recommendations on approaches for the nonclinical safety evaluation of oligonucleotide-based therapeutics (ONTs) to support clinical development and marketing of these products. ONTs present unique challenges and opportunities in the nonclinical evaluation of safety that differ in many regards from those appropriate for small molecule drugs or therapeutic proteins. 2024-11-15 2024 11 https://www.federalregister.gov/documents/2024/11/15/2024-26682/nonclinical-safety-assessment-of-oligonucleotide-based-therapeutics-draft-guidance-for-industry https://www.govinfo.gov/content/pkg/FR-2024-11-15/pdf/2024-26682.pdf Health and Human Services Department; Food and Drug Administration 221,199 The Food and Drug Administration (FDA or Agency) is announcing the availability of a draft guidance for industry entitled "Nonclinical Safety Assessment of Oligonucleotide-Based Therapeutics." FDA is publishing this draft guidance which, when...

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