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federal_register: 2021-27351

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document_number title type abstract publication_date pub_year pub_month html_url pdf_url agency_names agency_ids excerpts
2021-27351 Inspection of Injectable Products for Visible Particulates; Draft Guidance for Industry; Availability Notice The Food and Drug Administration (FDA or Agency) is announcing the availability of a draft guidance for industry entitled "Inspection of Injectable Products for Visible Particulates." Visible particulates in injectable products can jeopardize patient safety. This draft guidance addresses the development and implementation of a holistic, risk-based approach to visible particulate control that incorporates product development, manufacturing controls, visual inspection techniques, particulate identification, investigation, and corrective actions designed to assess, correct, and prevent the risk of visible particulate contamination. The draft guidance also clarifies that meeting an applicable U.S. Pharmacopeia (USP) compendial standard alone is not generally sufficient for meeting the current good manufacturing practice (CGMP) requirements for the manufacture of injectable products. 2021-12-17 2021 12 https://www.federalregister.gov/documents/2021/12/17/2021-27351/inspection-of-injectable-products-for-visible-particulates-draft-guidance-for-industry-availability https://www.govinfo.gov/content/pkg/FR-2021-12-17/pdf/2021-27351.pdf Health and Human Services Department; Food and Drug Administration 221,199 The Food and Drug Administration (FDA or Agency) is announcing the availability of a draft guidance for industry entitled "Inspection of Injectable Products for Visible Particulates." Visible particulates in injectable products can jeopardize patient...

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