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federal_register: 2019-25631

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document_number title type abstract publication_date pub_year pub_month html_url pdf_url agency_names agency_ids excerpts
2019-25631 Center for Devices and Radiological Health Ethylene Oxide Sterilization Master File Pilot Program Notice The Food and Drug Administration's (FDA or Agency or we) Center for Devices and Radiological Health (CDRH or Center) is announcing its Ethylene Oxide Sterilization Master File Pilot Program ("EtO Pilot Program"). The EtO Pilot Program is voluntary and intends to allow companies ("sterilization providers") that sterilize single- use medical devices using fixed chamber ethylene oxide (EtO) to submit a Master File when making certain changes between sterilization sites or when making certain changes to sterilization processes that utilize reduced EtO concentrations. Under this voluntary program, manufacturers ("PreMarket Application (PMA) holders") of Class III devices subject to premarket approval that are affected by such changes may, upon FDA's permission, reference the Master File submitted by their sterilization provider in a postapproval report in lieu of submission of a premarket approval application (PMA) supplement. The EtO Pilot Program seeks to help ensure patient access to safe medical devices while encouraging new, innovative ways to sterilize medical devices that reduce the potential impact of EtO on the environment and on the public health while providing a regulatory approach that would address potential device shortages. 2019-11-26 2019 11 https://www.federalregister.gov/documents/2019/11/26/2019-25631/center-for-devices-and-radiological-health-ethylene-oxide-sterilization-master-file-pilot-program https://www.govinfo.gov/content/pkg/FR-2019-11-26/pdf/2019-25631.pdf Health and Human Services Department; Food and Drug Administration 221,199 The Food and Drug Administration's (FDA or Agency or we) Center for Devices and Radiological Health (CDRH or Center) is announcing its Ethylene Oxide Sterilization Master File Pilot Program ("EtO Pilot Program"). The EtO Pilot Program is voluntary and...

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