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federal_register: 2019-25246

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document_number title type abstract publication_date pub_year pub_month html_url pdf_url agency_names agency_ids excerpts
2019-25246 Transdermal and Topical Delivery Systems-Product Development and Quality Considerations; Draft Guidance for Industry; Availability Notice The Food and Drug Administration (FDA or Agency) is announcing the availability of a draft guidance for industry entitled "Transdermal and Topical Delivery Systems--Product Development and Quality Considerations." This guidance provides recommendations to applicants and manufacturers of transdermal and topical delivery systems (TDS) regarding the pharmaceutical development and quality information to include in new drug applications (NDAs) and abbreviated new drug applications (ANDAs). Specifically, the guidance discusses FDA's current thinking on product design and pharmaceutical development, manufacturing process and control, and finished product control. It also addresses special considerations for areas where quality is closely tied to product performance and potential safety issues, such as adhesion failure and the impact of applied heat on drug delivery. 2019-11-21 2019 11 https://www.federalregister.gov/documents/2019/11/21/2019-25246/transdermal-and-topical-delivery-systems-product-development-and-quality-considerations-draft https://www.govinfo.gov/content/pkg/FR-2019-11-21/pdf/2019-25246.pdf Health and Human Services Department; Food and Drug Administration 221,199 The Food and Drug Administration (FDA or Agency) is announcing the availability of a draft guidance for industry entitled "Transdermal and Topical Delivery Systems--Product Development and Quality Considerations." This guidance provides recommendations...

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