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Regulatory documents from Regulations.gov including rules, proposed rules, notices, and supporting materials.

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19,805 rows where agency_id = "FDA" and document_type = "Notice" sorted by posted_date descending

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  • Notice · 19,805 ✖

agency_id 1

  • FDA · 19,805 ✖
id agency_id docket_id title document_type subtype posted_date ▲ posted_year posted_month comment_start_date comment_end_date last_modified fr_doc_num open_for_comment withdrawn object_id
FDA-2026-D-2698-0001 FDA Forms FDA 3542a and FDA 3542: Questions and Answers; Draft Guidance for Industry; Availability FDA-2026-D-2698 Forms FDA 3542a and FDA 3542: Questions and Answers; Draft Guidance for Industry; Availability Notice Notice of Availability 2026-06-15T04:00:00Z 2026 6     2026-06-15T17:12:16Z 2026-11966 0 0 09000064b932f27d
FDA-2026-N-0809-0040 FDA Recommendations on Scale-Up and Postapproval Changes Guidances for Industry; Request for Comments. FDA-2026-N-0809 Recommendations on Scale-Up and Postapproval Changes Guidances for Industry; Request for Comments; Reopening of the Comment Period Notice Request for Comments 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z 2026-03-04T04:59:59Z 2026-06-11T17:12:02Z 2026-11690 0 0 09000064b9324b04
FDA-2026-N-0498-0002 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Procedures for the Safe Processing and Importing of Fish and Fishery Products FDA-2026-N-0498 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Procedures for the Safe Processing and Importing of Fish and Fishery Products Notice 30 Day Proposed Information Collection 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z 2026-07-14T03:59:59Z 2026-06-11T17:38:55Z 2026-11762 1 0 09000064b93249f6
FDA-2025-N-4250-0003 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Establishment, Maintenance, and Availability of Records; Additional Traceability Records for Certain Foods FDA-2025-N-4250 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Establishment, Maintenance, and Availability of Records; Additional Traceability Records for Certain Foods Notice 30 Day Proposed Information Collection 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z 2026-07-14T03:59:59Z 2026-06-11T17:33:35Z 2026-11760 1 0 09000064b9324abc
FDA-2026-N-1832-0021 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1312 - Recombinant αs1-Casein from Bos taurus produced by E. coli (αs1-cn) Notice General Notice 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z   2026-06-11T22:59:48Z   0 0 09000064b9323675
FDA-2026-N-1832-0024 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1315 - Short-chain chondroitin sulfate oligosaccharides produced from enzymatic hydrolysis of chondroitin sulfate Notice General Notice 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z   2026-06-11T23:00:22Z   0 0 09000064b93244f7
FDA-2026-N-4492-0206 FDA Drug Repurposing for Unmet Medical Needs; Request for Information FDA-2026-N-4492 Drug Repurposing for Unmet Medical Needs; Request for Information; Extension of Comment Period Notice Extension of Comment Period 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z   2026-06-11T17:43:54Z 2026-11691 0 0 09000064b93249b7
FDA-2026-N-1832-0023 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1314 - Bacillus pumilus SG154 Strain Notice General Notice 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z   2026-06-11T23:00:15Z   0 0 09000064b93244f6
FDA-2026-N-1832-0022 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1313 - DHA-rich oil from Schizochytrium limacinum A2 Notice General Notice 2026-06-11T04:00:00Z 2026 6 2026-06-11T04:00:00Z   2026-06-11T22:59:53Z   0 0 09000064b9323676
FDA-2025-N-6494-0050 FDA Amending Over-the-Counter Monograph M020: Sunscreen Drug Products for Over-the-Counter Human Use FDA-2025-N-6494 Amending Over-the-Counter Monograph M020: Sunscreen Drug Products for Over-the-Counter Human Use, and Related Information Notice Announcement 2026-06-10T04:00:00Z 2026 6 2026-06-10T04:00:00Z   2026-06-10T21:18:04Z 2026-11578 0 0 09000064b93216d6
FDA-2026-N-5817-0001 FDA Determination That PROTAMINE SULFATE (Protamine Sulfate) Intravenous; Solution, 50 Milligrams/5 Milliliters, and Other Drug Products Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness FDA-2026-N-5817 Determination That Protamine Sulfate (Protamine Sulfate) Intravenous; Solution, 50 Milligrams/5 Milliliters, and Other Drug Products Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness Notice Determinations 2026-06-08T04:00:00Z 2026 6     2026-06-08T16:51:28Z 2026-11429 0 0 09000064b931b84b
FDA-2014-D-0967-0036 FDA Intent to Exempt Certain Unclassified, Class II, and Class I Reserved Medical Devices from Premarket Notification Requirements FDA-2014-D-0967 Intent To Exempt Certain Unclassified Medical Devices From Premarket Notification Requirements; Guidance for Industry and Food and Drug Administration Staff; Availability Notice Notice of Availability 2026-06-05T04:00:00Z 2026 6 2026-06-05T04:00:00Z   2026-06-05T17:22:43Z 2026-11303 0 0 09000064b93158a7
FDA-2016-D-1307-0036 FDA Questions and Answers Regarding Drug and Device Manufacturer Communications with Payors; Draft Guidance for Industry; Availability FDA-2016-D-1307 Drug and Device Manufacturer Communications With Payors, Formulary Committees, and Similar Entities—Questions and Answers; Revised Draft Guidance for Industry; Availability Notice Notice of Availability 2026-06-03T04:00:00Z 2026 6 2026-06-03T04:00:00Z   2026-06-03T18:20:20Z 2026-11060 0 0 09000064b930af49
FDA-2026-N-5816-0001 FDA Elite Laboratories, Inc. et al.; Withdrawal of Approval of 16 Abbreviated New Drug Applications FDA-2026-N-5816 Elite Laboratories, Inc. et al.; Withdrawal of Approval of 16 Abbreviated New Drug Applications Notice Withdrawal 2026-06-03T04:00:00Z 2026 6 2026-06-03T04:00:00Z   2026-06-03T18:17:35Z 2026-11062 0 0 09000064b930afcc
FDA-2024-N-2602-0009 FDA First Annual Animal Drug User Fee Educational Conference; Public Meeting FDA-2024-N-2602 Third Annual Animal Drug User Fee Educational Conference; Public Meeting Notice Meeting 2026-06-03T04:00:00Z 2026 6 2026-06-03T04:00:00Z   2026-06-05T09:00:13Z 2026-11101 1 0 09000064b930c159
FDA-2022-N-2390-0669 FDA Proposal To Refuse To Approve a New Drug Application Supplement for Hetlioz (Tasimelteon); Opportunity for a Hearing FDA-2022-N-2390 Vanda Pharmaceuticals, Inc.; Grant of Hearing Request Regarding a Proposal To Refuse To Approve a Supplemental New Drug Application for HETLIOZ (Tasimelteon) Notice Hearings 2026-06-03T04:00:00Z 2026 6 2026-06-03T04:00:00Z 2026-07-07T03:59:59Z 2026-06-03T17:59:58Z 2026-11046 1 0 09000064b930c153
FDA-2024-D-5580-0017 FDA M15 General Principles for Model-Informed Drug Development; International Council for Harmonisation; Draft Guidance for Industry; Availability FDA-2024-D-5580 M15 General Principles for Model-Informed Drug Development; International Council for Harmonisation; Guidance for Industry; Availability Notice Notice of Availability 2026-06-03T04:00:00Z 2026 6 2026-06-03T04:00:00Z   2026-06-03T18:07:07Z 2026-11112 0 0 09000064b930b0fe
FDA-2026-D-1257-0001 FDA Leveraging Prior Knowledge in the Development of Human Gene Therapy Products Incorporating Genome Editing; Draft Guidance for Industry; Availability FDA-2026-D-1257 Leveraging Prior Knowledge in the Development of Human Gene Therapy Products Incorporating Genome Editing; Draft Guidance for Industry; Availability Notice Notice of Availability 2026-06-03T04:00:00Z 2026 6 2026-06-03T04:00:00Z   2026-06-03T17:32:48Z 2026-11054 0 0 09000064b930c155
FDA-2026-D-2839-0001 FDA Oncology Pharmaceuticals: Streamlined Nonclinical Safety Studies for Biologics and Conjugated Products; Draft Guidance for Industry; Availability FDA-2026-D-2839 Oncology Pharmaceuticals: Streamlined Nonclinical Safety Studies for Biologics and Conjugated Products; Draft Guidance for Industry; Availability Notice Notice of Availability 2026-06-01T04:00:00Z 2026 6 2026-06-01T04:00:00Z   2026-06-01T17:32:10Z 2026-10873 0 0 09000064b9303ad2
FDA-2026-N-1832-0020 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1309 - D-psicose Notice General Notice 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T15:58:58Z   0 0 09000064b92f94a6
FDA-2026-N-1832-0017 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1305 - Brazzein preparation produced by Komagataella phaffii GDMCC 70101 expressing a gene encoding for brazzein from Pentadiplandra brazzeana Notice General Notice 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T15:57:49Z   0 0 09000064b92f94a0
FDA-2026-N-0008-0007 FDA Advisory Committee FDA-2026-N-0008 Advisory Committee; Psychopharmacologic Drugs Advisory Committee; Renewal Notice Notice of Renewal 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T17:13:43Z 2026-10674 0 0 09000064b92fcfad
FDA-2026-N-5057-0001 FDA Patient-Focused Drug Development for Nonhealing Chronic Wounds; Public Meeting; Request for Comments FDA-2026-N-5057 Patient-Focused Drug Development for Nonhealing Chronic Wounds; Public Meeting; Request for Comments Notice Request for Comments 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z 2026-10-27T03:59:59Z 2026-05-29T17:21:31Z 2026-10752 1 0 09000064b92fcf66
FDA-2015-D-4599-0037 FDA List of Highest Priority Devices for Human Factors Review FDA-2015-D-4599 Content of Human Factors Information in Medical Device Marketing Submissions; Guidance for Industry and Food and Drug Administration Staff; Availability Notice Notice of Availability 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T17:24:08Z 2026-10734 0 0 09000064b92fcd07
FDA-2013-D-1464-0022 FDA Draft Guidance for Industry on Bioequivalence Studies with Pharmacokinetic Endpoints for Drugs Submitted under an ANDA; Availability FDA-2013-D-1464 Bioequivalence Studies With Pharmacokinetic Endpoints for Drugs Submitted Under an Abbreviated New Drug Application; Guidance for Industry; Availability Notice Notice of Availability 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T17:16:39Z 2026-10703 0 0 09000064b92fcf69
FDA-2026-N-1832-0019 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1308 - Betaglucan produced by Kluyveromyces marxianus CGMCC 26703 Notice General Notice 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T15:58:36Z   0 0 09000064b92f94a5
FDA-2026-N-1832-0018 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1307 - Rebaudioside M produced by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni Notice General Notice 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T15:58:17Z   0 0 09000064b92f94a1
FDA-2001-D-0197-0020 FDA Statistical Approaches Establishing Bioequivalence FDA-2001-D-0197 Statistical Approaches To Establishing Bioequivalence; Guidance for Industry; Availability Notice Notice of Availability 2026-05-29T04:00:00Z 2026 5 2026-05-29T04:00:00Z   2026-05-29T17:47:18Z 2026-10705 0 0 09000064b92fcb6a
FDA-2026-N-4390-0048 FDA AI-Enabled Optimization of Early-Phase Clinical Trials Pilot Program; Request for Information FDA-2026-N-4390 AI-Enabled Optimization of Early-Phase Clinical Trials Pilot Program; Request for Information; Extension of Comment Period Notice Extension of Comment Period 2026-05-28T04:00:00Z 2026 5 2026-05-28T04:00:00Z   2026-05-28T17:26:35Z 2026-10602 0 0 09000064b92f8788
FDA-2014-N-0053-1369 FDA Designation of High-Risk Foods for Tracing; Request for Comments and for Scientific Data and Information FDA-2014-N-0053 Challenges and Solutions in Lot-Level Food Traceability; Public Meeting and Request for Comments Notice Request for Comments 2026-05-28T04:00:00Z 2026 5 2026-05-28T04:00:00Z 2026-07-16T03:59:59Z 2026-06-12T09:00:30Z 2026-10603 1 0 09000064b92f8854
FDA-1998-P-0083-0013 FDA Withdrawn From Sale of Tylosterone Tablets FDA-1998-P-0083 Drugs for Human Use; Drug Efficacy Study Implementation: Estrogen-Androgen Fixed-Combination Drug Products; Syntest D.S. and Syntest H.S. Tablets; Withdrawal of Hearing Requests; Final Resolution of Drug Efficacy Study Implementation 7661 Notice Withdrawal 2026-05-27T04:00:00Z 2026 5     2026-05-27T17:28:51Z 2026-10479 0 0 09000064b92f3c99
FDA-2026-N-0008-0006 FDA Advisory Committee FDA-2026-N-0008 Advisory Committee; Drug Safety and Risk Management Advisory Committee; Renewal Notice Notice of Renewal 2026-05-26T04:00:00Z 2026 5     2026-05-26T16:53:05Z 2026-10371 0 0 09000064b92f0633
FDA-2026-N-5128-0001 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Human Drug Compounding Under Sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act FDA-2026-N-5128 Agency Information Collection Activities; Proposed Collection; Comment Request; Human Drug Compounding Under Sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act Notice 60 Day Proposed Information Collection 2026-05-26T04:00:00Z 2026 5 2026-05-26T04:00:00Z 2026-07-28T03:59:59Z 2026-05-26T16:54:54Z 2026-10372 1 0 09000064b92f05ee
FDA-2026-N-0008-0005 FDA Advisory Committee FDA-2026-N-0008 Advisory Committee; Pulmonary-Allergy Drugs Advisory Committee; Renewal Notice Notice of Renewal 2026-05-26T04:00:00Z 2026 5     2026-05-26T16:52:52Z 2026-10410 0 0 09000064b92f06c5
FDA-2026-N-4162-0001 FDA Vaccines and Related Biological Products Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments - Safety and Effectiveness of MFLUSIVA (Influenza Vaccine, mRNA) manufactured by Moderna TX Inc. FDA-2026-N-4162 Vaccines and Related Biological Products Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for Comments—Safety and Effectiveness of MFLUSIVA (Influenza Vaccine, mRNA) Manufactured by Moderna TX Inc. Notice Request for Comments 2026-05-22T04:00:00Z 2026 5 2026-05-22T04:00:00Z 2026-06-18T03:59:59Z 2026-06-15T09:00:18Z 2026-10321 1 0 09000064b92ecd0e
FDA-2007-D-0369-2531 FDA Industry Describing Product-Specific Bioequivalence Recommendations FDA-2007-D-0369 Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability Notice Notice of Availability 2026-05-22T04:00:00Z 2026 5 2026-05-22T04:00:00Z   2026-05-22T17:26:17Z 2026-10277 0 0 09000064b92ecd58
FDA-2022-D-3054-0036 FDA M11 Clinical Electronic Structured Harmonised Protocol (CeSHarP); International Council for Harmonisation; Draft Guidance for Industry; Draft Template; and Technical Specification; Availability FDA-2022-D-3054 M11 Clinical Electronic Structured Harmonised Protocol (CeSHarP); International Council for Harmonisation; Guidance for Industry; Availability Notice Notice of Availability 2026-05-22T04:00:00Z 2026 5 2026-05-22T04:00:00Z   2026-05-22T18:37:34Z 2026-10295 0 0 09000064b92ec40f
FDA-2008-N-0567-0198 FDA Designating Additions to the Current List of Tropical Diseases in Section 1102 of the Food and Drug Administration Amendments Act FDA-2008-N-0567 Notice of Decision Not To Designate Hepatitis Delta Virus Diseases as an Addition to the Current List of Tropical Diseases in the Federal Food, Drug, and Cosmetic Act Notice General Notice 2026-05-22T04:00:00Z 2026 5 2026-05-22T04:00:00Z   2026-05-26T21:16:59Z 2026-10268 1 0 09000064b92ecd55
FDA-2022-D-2424-0012 FDA Protein Efficiency Ratio (PER) Rat Bioassay Studies to Demonstrate that a New Infant Formula Supports the Quality Factor of Sufficient Biological Quality of Protein; Draft Guidance for Industry; Availability; Agency Information Collection Activities; Proposed Collection; Comment Request FDA-2022-D-2424 Protein Efficiency Ratio Rat Bioassay Studies To Demonstrate That a New Infant Formula Supports the Quality Factor of Sufficient Biological Quality of Protein; Guidance for Industry; Availability Notice Notice of Availability 2026-05-22T04:00:00Z 2026 5 2026-05-22T04:00:00Z   2026-05-22T19:00:07Z 2026-10284 0 0 09000064b92ec387
FDA-2026-N-0497-0002 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Patent Term Restoration; Due Diligence Petitions; Filing, Format, and Content of Petitions FDA-2026-N-0497 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Patent Term Restoration; Due Diligence Petitions; Filing, Format, and Content of Petitions Notice 30 Day Proposed Information Collection 2026-05-21T04:00:00Z 2026 5 2026-05-21T04:00:00Z 2026-06-23T03:59:59Z 2026-05-21T17:10:24Z 2026-10190 1 0 09000064b92e83b1
FDA-2026-N-1303-0002 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Adverse Events Associated With New Animal Drugs FDA-2026-N-1303 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Adverse Experience/Events With Approved New Animal Drugs Notice 30 Day Proposed Information Collection 2026-05-21T04:00:00Z 2026 5 2026-05-21T04:00:00Z 2026-06-23T03:59:59Z 2026-05-21T17:05:09Z 2026-10189 1 0 09000064b92e83b8
FDA-2026-N-0746-0005 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Current Good Manufacturing Practice (CGMP): Manufacturing, Processing, Packing, and Holding of Drugs; GMP for Finished Pharmaceuticals (Including Active Pharmaceutical Ingredients) and the Advanced Manufacturing Technologies Designation Program FDA-2026-N-0746 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Current Good Manufacturing Practice (CGMP): Manufacturing, Processing, Packing, and Holding of Drugs; GMP for Finished Pharmaceuticals (Including Active Pharmaceutical Ingredients) and the Advanced Manufacturing Technologies Designation Program Notice 30 Day Proposed Information Collection 2026-05-21T04:00:00Z 2026 5 2026-05-21T04:00:00Z 2026-06-23T03:59:59Z 2026-05-21T16:54:56Z 2026-10188 1 0 09000064b92e8437
FDA-2025-N-6076-0004 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Required Warnings for Cigarette Packages and Advertisements FDA-2025-N-6076 Agency Information Collection Activities; Proposals, Submissions, and Approvals: Required Warnings for Cigarette Packages and Advertisements Notice 30 Day Proposed Information Collection 2026-05-21T04:00:00Z 2026 5 2026-05-21T04:00:00Z 2026-06-23T03:59:59Z 2026-05-21T20:57:01Z 2026-10187 1 0 09000064b92e9178
FDA-2026-N-1832-0016 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1294 – Rebaudioside M produced by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni – amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:46:40Z   0 0 09000064b92e1248
FDA-2025-N-1928-0070 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1250 - Alternansucrase enzyme preparation produced by Escherichia coli expressing the gene encoding alternansucrase from Leuconostoc mesenteroides - amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:44:43Z   0 0 09000064b92e1210
FDA-2025-N-1928-0076 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1272 - Lacto-N-neotetraose - amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:48Z   0 0 09000064b92e122d
FDA-2025-N-1928-0071 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1253 - Lycopene preparation produced by Saccharomyces cerevisiae JZL03 - amendment Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:19Z   0 0 09000064b92e1212
FDA-2025-N-1928-0074 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1262 - 2'-Fucosyllactose - amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:37Z   0 0 09000064b92e1218
FDA-2025-N-1928-0073 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1258 - Lacto-N-tetraose - amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:32Z   0 0 09000064b92e1216
FDA-2025-N-1928-0077 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1273 - Lacto-N-tetraose - amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:54Z   0 0 09000064b92e122f
FDA-2025-N-1928-0075 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1263 - Bacillus coagulans PTA-127366 spore preparation - amendment Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:42Z   0 0 09000064b92e122b
FDA-2025-N-1928-0078 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1292 - Citrus-derived compounded sweetener made with neohesperidin dihydrochalcone and gamma cyclodextrin - amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:59Z   0 0 09000064b92e1231
FDA-2025-N-1928-0072 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1257 - 2’-Fucosyllactose - amendments Notice General Notice 2026-05-19T04:00:00Z 2026 5 2026-05-19T04:00:00Z   2026-05-19T22:45:26Z   0 0 09000064b92e1214
FDA-2025-N-0421-0002 FDA NOOH Proposal to Debar Oscar Bobo FDA-2025-N-0421 Oscar Bobo: Final Debarment Order Notice Statutory Debarment 2026-05-15T04:00:00Z 2026 5 2026-05-15T04:00:00Z   2026-05-15T17:48:54Z 2026-09767 1 0 09000064b92da9bd
FDA-2026-N-4126-0001 FDA Azodicarbonamide (ADA); Request for Information FDA-2026-N-4126 Azodicarbonamide (ADA); Request for Information Notice Requests for Information (RFI) 2026-05-13T04:00:00Z 2026 5 2026-05-13T04:00:00Z 2026-07-14T03:59:59Z 2026-05-13T17:13:38Z 2026-09508 1 0 09000064b92d17fd
FDA-2026-N-3098-0001 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Postmarketing Adverse Experience Reporting FDA-2026-N-3098 Agency Information Collection Activities; Proposed Collection; Comment Request; Postmarketing Adverse Experience Reporting Notice 60 Day Proposed Information Collection 2026-05-13T04:00:00Z 2026 5 2026-05-13T04:00:00Z 2026-07-14T03:59:59Z 2026-05-13T16:56:28Z 2026-09543 1 0 09000064b92d4966
FDA-2019-N-0994-0230 FDA Modified Risk Tobacco Product Applications for VLN™ King and VLN™ Menthol King, Combusted, Filtered Cigarettes, Submitted by 22nd Century Group Inc. FDA-2019-N-0994 Modified Risk Tobacco Product Application: Renewal Applications for VLN® King and VLN® Menthol King, Cigarette Products Submitted by 22nd Century Group Inc. Notice Request for Comments 2026-05-13T04:00:00Z 2026 5 2026-05-13T04:00:00Z   2026-05-27T09:00:28Z 2026-09544 1 0 09000064b92d47df
FDA-2026-N-2526-0001 FDA Butylated hydroxytoluene (BHT); Request for Information FDA-2026-N-2526 Butylated Hydroxytoluene (BHT); Request for Information Notice Requests for Information (RFI) 2026-05-13T04:00:00Z 2026 5 2026-05-13T04:00:00Z 2026-07-14T03:59:59Z 2026-05-28T09:00:18Z 2026-09507 1 0 09000064b92d4931
FDA-2025-N-1600-0003 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; The Real Cost Campaign Outcomes Evaluation Study: Cohort 3 FDA-2025-N-1600 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; The Real Cost Campaign Outcomes Evaluation Study: Cohort 3 Notice 30 Day Proposed Information Collection 2026-05-13T04:00:00Z 2026 5 2026-05-13T04:00:00Z 2026-06-13T03:59:59Z 2026-05-13T17:17:21Z 2026-09448 0 0 09000064b92d4828
FDA-2026-N-0005-0001 FDA Public Seminar FDA-2026-N-0005 Biomarker Incubator: Urinary Kidney Safety Biomarkers; Request for Information Notice Requests for Information (RFI) 2026-05-13T04:00:00Z 2026 5 2026-05-13T04:00:00Z 2026-07-14T03:59:59Z 2026-05-20T09:00:17Z 2026-09533 1 0 09000064b92d48f3
FDA-2026-N-4492-0001 FDA Drug Repurposing for Unmet Medical Needs; Request for Information FDA-2026-N-4492 Drug Repurposing for Unmet Medical Needs; Request for Information Notice Requests for Information (RFI) 2026-05-12T04:00:00Z 2026 5 2026-05-12T04:00:00Z 2026-07-14T03:59:59Z 2026-06-15T09:00:15Z 2026-09366 1 0 09000064b92d15f4
FDA-2017-N-5925-0040 FDA Standard Development Organizations Whose Susceptibility Test Interpretive Criteria Standards May Be Recognized by FDA FDA-2017-N-5925 21st Century Cures Act: Annual Compilation of Notices of Updates From the Susceptibility Test Interpretive Criteria web page Notice Request for Comments 2026-05-12T04:00:00Z 2026 5 2026-05-12T04:00:00Z   2026-05-12T22:58:36Z 2026-09438 1 0 09000064b92d17af
FDA-2026-D-5083-0001 FDA Enforcement Policies for Certain Electronic Nicotine Delivery Systems (ENDS) Marketed Without Premarket Authorization; Guidance for Industry; Availability FDA-2026-D-5083 Enforcement Priorities for Certain New Tobacco Products Marketed Without Premarket Authorization; Guidance for Industry; Availability Notice Notice of Availability 2026-05-12T04:00:00Z 2026 5 2026-05-12T04:00:00Z   2026-05-12T17:17:05Z 2026-09368 0 0 09000064b92d1762
FDA-2025-N-2220-0002 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Testing Communications On Medical Devices and Radiation-Emitting Products FDA-2025-N-2220 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Testing Communications On Medical Devices and Radiation-Emitting Products Notice 30 Day Proposed Information Collection 2026-05-11T04:00:00Z 2026 5 2026-05-11T04:00:00Z 2026-06-11T03:59:59Z 2026-06-11T09:00:16Z 2026-09244 0 0 09000064b92cfa18
FDA-2011-N-0655-0042 FDA Animal Generic Drug User Fee Act; Public Meeting FDA-2011-N-0655 Animal Generic Drug User Fee Act; Stakeholder Consultation Meetings on the Animal Generic Drug User Fee Act Reauthorization; Request for Notification of Stakeholder Intent To Participate Notice Notice of Intent 2026-05-11T04:00:00Z 2026 5 2026-05-11T04:00:00Z   2026-05-11T21:26:21Z 2026-09284 0 0 09000064b92cf91b
FDA-2026-N-4573-0001 FDA Issuance of Priority Review Voucher; Rare Pediatric Disease Product; AVLAYAH (tividenofusp alfa-eknm) FDA-2026-N-4573 Issuance of Priority Review Voucher; Rare Pediatric Disease Product; AVLAYAH (tividenofusp alfa-eknm) Notice Announcement 2026-05-11T04:00:00Z 2026 5 2026-05-11T04:00:00Z   2026-05-11T17:34:15Z 2026-09242 0 0 09000064b92cf987
FDA-2013-D-1319-0015 FDA Draft Guidance for Industry on Pulmonary Tuberculosis: Developing Drugs for Treatment; Availability FDA-2013-D-1319 Pulmonary Tuberculosis: Developing Drugs for Treatment; Guidance for Industry; Availability Notice Notice of Availability 2026-05-11T04:00:00Z 2026 5 2026-05-11T04:00:00Z   2026-05-11T17:27:37Z 2026-09269 0 0 09000064b92cf98a
FDA-2018-D-4693-0022 FDA Postapproval Pregnancy Safety Studies; Draft Guidance for Industry; Availability FDA-2018-D-4693 Postapproval Pregnancy Safety Studies; Guidance for Industry; Availability Notice Notice of Availability 2026-05-11T04:00:00Z 2026 5 2026-05-11T04:00:00Z   2026-05-11T17:36:17Z 2026-09268 0 0 09000064b92cf982
FDA-2011-N-0656-1315 FDA Animal Drug User Fee Act; Public Meeting FDA-2011-N-0656 Animal Drug User Fee Act; Stakeholder Consultation Meetings on the Animal Drug User Fee Act Reauthorization; Request for Notification of Stakeholder Intent To Participate Notice General Notice 2026-05-11T04:00:00Z 2026 5 2026-05-11T04:00:00Z   2026-05-11T17:56:32Z 2026-09283 0 0 09000064b92cacd0
FDA-2022-D-1261-0003 FDA Clostridioides difficile Infection: Developing Drugs for Treatment, Reduction of Recurrence, and Prevention; Draft Guidance for Industry; Availability FDA-2022-D-1261 Clostridioides Difficile Infection: Developing Drugs for Treatment, Reduction of Recurrence, or Prevention; Guidance for Industry; Availability Notice Notice of Availability 2026-05-11T04:00:00Z 2026 5 2026-05-11T04:00:00Z   2026-05-11T17:42:11Z 2026-09267 0 0 09000064b92cf922
FDA-2026-P-0749-0004 FDA Requests that the FDA determine whether Leucovorin Calcium For Oral Solution, EQ 60 mg base/vial, (NDA 008107) held by Hospira Inc. has been voluntarily withdrawn or withheld from sale for reasons of safety or efficacy FDA-2026-P-0749 Determination That Leucovorin Calcium, Oral Solution, Equivalent to 60 Milligrams Base/Vial, Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness Notice Determinations 2026-05-08T04:00:00Z 2026 5     2026-05-08T17:04:13Z 2026-09199 0 0 09000064b92c97d0
FDA-2025-P-7054-0006 FDA Request that the FDA determine whether the Reference Listed Drug (RLD) MICARDIS (Telmisartan Tablets, 20 mg and 80 mg) under New Drug Application (NDA) N020850 held by Boehringer Ingelheim, was voluntarily withdrawn from commercial distribution or withdrawn from sale for safety or efficacy reasons FDA-2025-P-7054 Determination That MICARDIS (Telmisartan), Tablets, 20 Milligrams and 80 Milligrams, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness Notice Determinations 2026-05-07T04:00:00Z 2026 5 2026-05-07T04:00:00Z   2026-05-07T17:15:35Z 2026-09011 0 0 09000064b92c66bf
FDA-2023-D-2370-0007 FDA Patient-Matched Guides to Orthopedic Implants; Draft Guidance for Industry and Food and Drug Administration Staff; Draft Guidance for Industry and Food and Drug Administration Staff; Availability FDA-2023-D-2370 Patient-Matched Guides for Orthopedic Implants; Guidance for Industry and Food and Drug Administration Staff; Availability Notice Notice of Availability 2026-05-07T04:00:00Z 2026 5 2026-05-07T04:00:00Z   2026-05-07T17:05:32Z 2026-09023 0 0 09000064b92c78fc
FDA-2026-N-4291-0001 FDA Teva Pharmaceuticals USA, Inc., et al.; Withdrawal of Approval of 15 Abbreviated New Drug Applications FDA-2026-N-4291 Teva Pharmaceuticals USA, Inc., et al.; Withdrawal of Approval of 15 Abbreviated New Drug Applications Notice Withdrawal 2026-05-07T04:00:00Z 2026 5 2026-05-07T04:00:00Z   2026-05-07T16:54:25Z 2026-09012 0 0 09000064b92c85aa
FDA-2026-N-0008-0004 FDA Advisory Committee FDA-2026-N-0008 Advisory Committee; Blood Products Advisory Committee; Renewal Notice Notice of Renewal 2026-05-07T04:00:00Z 2026 5 2026-05-07T04:00:00Z   2026-05-07T17:02:15Z 2026-09108 0 0 09000064b92c85a3
FDA-2026-N-4588-0001 FDA Issuance of Priority Review Voucher; Rare Pediatric Disease Product; OTARMENI (lunsotogene parvec-cwha) FDA-2026-N-4588 Issuance of Priority Review Voucher; Rare Pediatric Disease Product; OTARMENI (lunsotogene parvec-cwha) Notice Announcement 2026-05-06T04:00:00Z 2026 5 2026-05-06T04:00:00Z   2026-05-06T17:40:41Z 2026-08913 0 0 09000064b92c5bca
FDA-2026-P-1306-0004 FDA Requests that the FDA to determine whether the Reference Listed Drug (RLD) DEXAMETHASONE ELIXIR, 0.5 mg/5 mL; Abbreviated New Drug Application (ANDA) 088254 of PHARMOBEDIENT CONSULTING has been voluntarily withdrawn from sale for safety or efficacy reasons. FDA-2026-P-1306 Determination That DEXAMETHASONE (Dexamethasone) Elixir, 0.5 Milligrams/5 Milliliters, Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness Notice Determinations 2026-05-06T04:00:00Z 2026 5 2026-05-06T04:00:00Z   2026-05-06T17:34:01Z 2026-08939 0 0 09000064b92c65a4
FDA-2026-N-3070-0001 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; National Youth Tobacco Survey FDA-2026-N-3070 Agency Information Collection Activities; Proposed Collection; Comment Request; National Youth Tobacco Survey Notice 60 Day Proposed Information Collection 2026-05-04T04:00:00Z 2026 5 2026-05-04T04:00:00Z 2026-07-07T03:59:59Z 2026-05-04T19:19:25Z 2026-08604 1 0 09000064b92c115c
FDA-2018-N-3240-0377 FDA List of Bulk Drug Substances For Which There Is a Clinical Need Under Section 503B of the Federal Food, Drug, and Cosmetic Act; Notice FDA-2018-N-3240 List of Bulk Drug Substances for Which There Is a Clinical Need Under Section 503B of the Federal Food, Drug, and Cosmetic Act Notice Request for Comments 2026-05-01T04:00:00Z 2026 5 2026-05-01T04:00:00Z 2026-07-01T03:59:59Z 2026-06-15T09:00:13Z 2026-08552 1 0 09000064b92bb724
FDA-2026-N-3499-0001 FDA Obesity and Drug Dosing: Clinical Pharmacology Considerations; Request for Comments FDA-2026-N-3499 Obesity and Drug Dosing: Clinical Pharmacology Considerations; Request for Comments Notice Request for Comments 2026-05-01T04:00:00Z 2026 5 2026-05-01T04:00:00Z 2026-07-01T03:59:59Z 2026-05-02T09:00:17Z 2026-08521 1 0 09000064b92bb7fb
FDA-2026-N-3947-0001 FDA Impacts of Patient-Focused Drug Development Meetings; Establishment of a Public Docket; Request for Information and Comments FDA-2026-N-3947 Impacts of Patient-Focused Drug Development Meetings; Establishment of a Public Docket; Request for Information and Comments Notice Request for Comments 2026-05-01T04:00:00Z 2026 5 2026-05-01T04:00:00Z 2026-07-01T03:59:59Z 2026-06-13T09:00:11Z 2026-08524 1 0 09000064b92bb6d7
FDA-2026-N-4268-0001 FDA Medical Devices; Exemptions from Premarket Notification: Certain Class II Devices; Request for Comments FDA-2026-N-4268 Medical Devices; Exemptions From Premarket Notification: Certain Class II Devices; Request for Comments Notice Request for Comments 2026-05-01T04:00:00Z 2026 5 2026-05-01T04:00:00Z 2026-07-01T03:59:59Z 2026-06-13T09:00:11Z 2026-08499 1 0 09000064b92bb7b3
FDA-2026-N-0499-0002 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Hazard Analysis and Critical Control Point Procedures for the Safe and Sanitary Processing and Importing of Juice FDA-2026-N-0499 Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Hazard Analysis and Critical Control Point Procedures for the Safe and Sanitary Processing and Importing of Juice Notice 30 Day Proposed Information Collection 2026-04-30T04:00:00Z 2026 4 2026-04-30T04:00:00Z 2026-06-02T03:59:59Z 2026-06-02T09:00:30Z 2026-08417 0 0 09000064b92b80f2
FDA-2026-P-0655-0003 FDA Request that the FDA determine that the listed RLD product FENOGLIDE (fenofibrate) Tablets, 40 mg and 120 mg, N022118, NDA Holder– Salix Pharmaceuticals INC, was not discontinued for safety or effectiveness reasons FDA-2026-P-0655 Determination FENOGLIDE (Fenofibrate) Tablets, 40 Milligrams and 120 Milligrams, Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness Notice Determinations 2026-04-30T04:00:00Z 2026 4     2026-04-30T17:56:39Z 2026-08390 0 0 09000064b92b7f6c
FDA-2026-N-0008-0003 FDA Advisory Committee FDA-2026-N-0008 Advisory Committee; Pharmacy Compounding Advisory Committee; Renewal Notice Notice of Renewal 2026-04-30T04:00:00Z 2026 4     2026-04-30T18:03:08Z 2026-08378 0 0 09000064b92b7f20
FDA-2025-P-3849-0004 FDA Requests that the FDA determine whether OZEMPIC (semaglutide) Injection, 2 mg/1.5 mL (1.34 mg/mL) was withdrawn for safety or effectiveness reasons. FDA-2025-P-3849 Determination That OZEMPIC (Semaglutide) Solution, 2 Milligrams Per 1.5 Milliliters Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness Notice Determinations 2026-04-30T04:00:00Z 2026 4     2026-04-30T18:12:42Z 2026-08435 0 0 09000064b92b5df8
FDA-2026-N-3532-0001 FDA Agency Information Collection Activities; Proposed Collection; Comment Request; Good Laboratory Practice Requirements for Nonclinical Laboratory Studies FDA-2026-N-3532 Agency Information Collection Activities; Proposed Collection; Comment Request; Good Laboratory Practice Requirements for Nonclinical Laboratory Studies Notice 60 Day Proposed Information Collection 2026-04-30T04:00:00Z 2026 4 2026-04-30T04:00:00Z 2026-06-30T03:59:59Z 2026-05-02T09:00:17Z 2026-08371 1 0 09000064b92b7fb3
FDA-2026-N-1321-0001 FDA ChemoCentryx, Inc.; Proposal To Withdraw Approval of New Drug Application for TAVNEOS (Avacopan) Capsule, 10 Milligrams; Opportunity for a Hearing FDA-2026-N-1321 ChemoCentryx, Inc.; Proposal To Withdraw Approval of New Drug Application for TAVNEOS (Avacopan) Capsule, 10 Milligrams; Opportunity for a Hearing Notice Withdrawal 2026-04-30T04:00:00Z 2026 4 2026-04-30T04:00:00Z 2026-06-30T03:59:59Z 2026-06-12T09:00:26Z 2026-08455 1 0 09000064b92b7e81
FDA-2026-N-4390-0001 FDA AI-Enabled Optimization of Early-Phase Clinical Trials Pilot Program; Request for Information FDA-2026-N-4390 AI-Enabled Optimization of Early- Phase Clinical Trials Pilot Program; Request for Information Notice Requests for Information (RFI) 2026-04-29T04:00:00Z 2026 4 2026-04-29T04:00:00Z 2026-06-30T03:59:59Z 2026-06-15T09:00:13Z 2026-08281 1 0 09000064b92b54c8
FDA-2026-N-1832-0014 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1303 - Bifidobacterium animalis subsp. lactis CGMCC5470 Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:29:48Z   0 0 09000064b92a8cd6
FDA-2025-N-1928-0067 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1279 – Saccharomyces cerevisiae CCTCC M2025194 – amendments Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:24:49Z   0 0 09000064b92a80fa
FDA-2026-N-1832-0008 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1297 - Enzyme-hydrolyzed brown rice protein - Part 3 of 3 Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:28:45Z   0 0 09000064b92a8ccc
FDA-2025-N-1928-0066 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1278 – Lactiplantibacillus plantarum CGMCC 6312 – amendments Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:24:47Z   0 0 09000064b92a80f9
FDA-2025-N-1928-0064 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1256 – Lemna leaf protein – amendments Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:18:46Z   0 0 09000064b92a80f7
FDA-2026-N-1832-0007 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1297 - Enzyme-hydrolyzed brown rice protein - Part 2 of 3 Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:28:26Z   0 0 09000064b92a8ccb
FDA-2025-N-1928-0065 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1276 – Cellulase enzyme preparation produced by Trichoderma reesei expressing a gene encoding a cellulase from Aspergillus niger – amendments Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:24:37Z   0 0 09000064b92a80f8
FDA-2026-N-1832-0015 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1304 - Preparation containing at least three bacteriophages (phage) specific to Listeria spp. Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:29:52Z   0 0 09000064b92a8cd7
FDA-2026-N-1832-0003 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1293 - Brazzein preparation produced by Komagataella phaffii “RA-b” expressing a gene encoding for brazzein from Pentadiplandra brazzeana - Part 2 of 2 Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:27:02Z   0 0 09000064b92a8cc6
FDA-2026-N-1832-0005 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2026 FDA-2026-N-1832 GRAS Notice (GRN) 1295 - Brazzein preparation produced by Komagataella phaffii GS115 expressing a gene encoding for brazzein from Pentadiplandra brazzeana Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:27:45Z   0 0 09000064b92a8cc9
FDA-2025-N-1928-0069 FDA Generally Recognized as Safe (GRAS) Notices Filed in 2025 FDA-2025-N-1928 GRAS Notice (GRN) 1296 - Erythritol produced through fermentation of glucose by Yarrowia lipolytica Notice General Notice 2026-04-28T04:00:00Z 2026 4 2026-04-28T04:00:00Z   2026-04-28T16:25:01Z   0 0 09000064b92a80fc

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CREATE TABLE documents (
    id TEXT PRIMARY KEY,
    agency_id TEXT,
    docket_id TEXT REFERENCES dockets(id),
    title TEXT,
    document_type TEXT,
    subtype TEXT,
    posted_date TEXT,
    posted_year INTEGER,
    posted_month INTEGER,
    comment_start_date TEXT,
    comment_end_date TEXT,
    last_modified TEXT,
    fr_doc_num TEXT,
    open_for_comment INTEGER,
    withdrawn INTEGER,
    object_id TEXT
);
CREATE INDEX idx_docs_agency ON documents(agency_id);
CREATE INDEX idx_docs_docket ON documents(docket_id);
CREATE INDEX idx_docs_date ON documents(posted_date);
CREATE INDEX idx_docs_year ON documents(posted_year);
CREATE INDEX idx_docs_type ON documents(document_type);
CREATE INDEX idx_docs_frnum ON documents(fr_doc_num);
CREATE INDEX idx_docs_comment_end ON documents(comment_end_date) WHERE comment_end_date IS NOT NULL AND withdrawn = 0;
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