id,agency_id,docket_id,title,document_type,subtype,posted_date,posted_year,posted_month,comment_start_date,comment_end_date,last_modified,fr_doc_num,open_for_comment,withdrawn,object_id EPA-HQ-OAR-2004-0074-0265,EPA,EPA-HQ-OAR-2004-0074,"Letter from Margo T. Oge, Director, Office of Mobile Sources, EPA to Donald R. Lynam, Ph.D, CIH, P.E., Vice President, Air Conservation Ethyl Corporation [A-98-35-III-A-1]",Supporting & Related Material,,2024-05-28T04:00:00Z,2024,5,,,2024-05-28T14:38:49Z,,0,0,09000064846afb99 EPA-HQ-OAR-2004-0074-0262,EPA,EPA-HQ-OAR-2004-0074,"Letter from Merrylin Zaw-Mon, Director Transportation and Regional Programs Division [A-98-35-V-A-3]",Supporting & Related Material,Letter,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:49Z,,0,0,09000064846afc89 EPA-HQ-OAR-2004-0074-0257,EPA,EPA-HQ-OAR-2004-0074,"Letter from Timothy D. Backstrom, ( EPA Counsel, to F. William Brownell, Esq. Hunton & William for Ethyl Corporation [A-98-35-III-B-1]",Supporting & Related Material,Letter,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:46Z,,0,0,09000064846afc84 EPA-HQ-OAR-2004-0074-0256,EPA,EPA-HQ-OAR-2004-0074,"Federal Register of Tuesday, February 9, 1999 (64 FR 6394) (FRL-6231-91) [A-98-35-III-A-3]",Supporting & Related Material,Publication - Previous/Related FR Notice,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:46Z,,0,0,09000064846afc83 EPA-HQ-OAR-2004-0074-0263,EPA,EPA-HQ-OAR-2004-0074,"Federal Register of Wednesday, July 19, 2000 (65 FR 44775) (FRL-6837-4) [A-98-35-V-A-4]",Supporting & Related Material,Publication - Previous/Related FR Notice,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:51Z,,0,0,09000064846afc8a EPA-HQ-OAR-2004-0074-0264,EPA,EPA-HQ-OAR-2004-0074,"Characterization of Manganese Particulates from Vehicles Using MMT Fuel, A Compilation of Results from studies performed, by Lawrence Livermore National Laboratory Southwest Research Institute University of Minnesota Research Triangle Institute Ethyl Research and Developmen, September 10, 1997. [A-98-35-II-B-01]",Supporting & Related Material,Report,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:51Z,,0,0,09000064846afc8b EPA-HQ-OAR-2004-0074-0255,EPA,EPA-HQ-OAR-2004-0074,"Letter from Deborah K. Wood, Acting Director Fuels and Energy Division,[A-98-35-III-A-2]",Supporting & Related Material,Letter,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:45Z,,0,0,09000064846afb9a EPA-HQ-OAR-2004-0074-0261,EPA,EPA-HQ-OAR-2004-0074,"Letter from Margo T. Oge, Director, Office of Transportation and Air Quality, Donald R. Lynam, Ph.D., CIH, P.E. Vice President, Air Conservation Ethyl Corporation [A-98-35-V-A-2]",Supporting & Related Material,Letter,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:49Z,,0,0,09000064846afc88 EPA-HQ-OAR-2004-0074-0259,EPA,EPA-HQ-OAR-2004-0074,"Letter from Timothy D. Backstrom, EPA Counsel to Kevin L. Fast, Esq. Hunton & Williams for Ethyl Corporation [A-98-35-III-B-3]",Supporting & Related Material,Letter,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:47Z,,0,0,09000064846afc86 EPA-HQ-OAR-2004-0074-0260,EPA,EPA-HQ-OAR-2004-0074,"Letter from Margo T. Oge, Director, Office of Transportation and Air Quality to Donald R. Lynam, Ph.D., CIH, P.E. Vice President, Air Conservation Ethyl Corporation [A-98-35-V-A-1]",Supporting & Related Material,Letter,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:48Z,,0,0,09000064846afc87 EPA-HQ-OAR-2004-0074-0258,EPA,EPA-HQ-OAR-2004-0074,"Letter from Timothy D. Backstrom, ( EPA Counsel, to F. William Brownell, Esq. Hunton & William for Ethyl Corporation [A-98-35-III-B-2]",Supporting & Related Material,Letter,2024-01-02T05:00:00Z,2024,1,,,2024-01-02T14:49:47Z,,0,0,09000064846afc85 EPA-HQ-OAR-2004-0074-0246,EPA,EPA-HQ-OAR-2004-0074,Song - Addition Of Drinking Water To Rat And Human Mn PBPK Model Paper,Supporting & Related Material,Publication,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:14Z,,0,0,0900006484738ddb EPA-HQ-OAR-2004-0074-0251,EPA,EPA-HQ-OAR-2004-0074,Andersen Monkey Transporter Presentation 3.19.2020,Supporting & Related Material,Meeting Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:16Z,,0,0,090000648478dc22 EPA-HQ-OAR-2004-0074-0240,EPA,EPA-HQ-OAR-2004-0074,Clewell Mn TAP PBPK Background,Supporting & Related Material,Meeting Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:10Z,,0,0,0900006484738a6d EPA-HQ-OAR-2004-0074-0241,EPA,EPA-HQ-OAR-2004-0074,Gentry - PBPK Model Applications,Supporting & Related Material,Meeting Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:11Z,,0,0,0900006484738a6e EPA-HQ-OAR-2004-0074-0247,EPA,EPA-HQ-OAR-2004-0074,Yoon - Mn PBPK Dev Drinking Water Paper (002),Supporting & Related Material,Publication,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:14Z,,0,0,0900006484738ddd EPA-HQ-OAR-2004-0074-0239,EPA,EPA-HQ-OAR-2004-0074,History of Manganese Modeling 2020,Supporting & Related Material,Report,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:10Z,,0,0,0900006484738a6c EPA-HQ-OAR-2004-0074-0250,EPA,EPA-HQ-OAR-2004-0074,Andersen Mn Rat Transporter Model TAP 3.19.20,Supporting & Related Material,Meeting Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:16Z,,0,0,090000648478d456 EPA-HQ-OAR-2004-0074-0242,EPA,EPA-HQ-OAR-2004-0074,Mn Margins of Safety Paper,Supporting & Related Material,Publication - Copyrighted Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:11Z,,0,0,0900006484738a6f EPA-HQ-OAR-2004-0074-0245,EPA,EPA-HQ-OAR-2004-0074,Foster Dorman - Rat Drinking Water Paper,Supporting & Related Material,Publication - Copyrighted Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:13Z,,0,0,0900006484738a72 EPA-HQ-OAR-2004-0074-0236,EPA,EPA-HQ-OAR-2004-0074,Afton Chemical Corporation Letter transmitting availability of manganese PBPK models and Technical Advisory Panel meeting results,Supporting & Related Material,Letter,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:08Z,,0,0,0900006484738233 EPA-HQ-OAR-2004-0074-0243,EPA,EPA-HQ-OAR-2004-0074,Clewell - Drinking Water Models,Supporting & Related Material,Meeting Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:12Z,,0,0,0900006484738a70 EPA-HQ-OAR-2004-0074-0237,EPA,EPA-HQ-OAR-2004-0074,"Report of the Technical Advisory Panel meeting for Manganese PBPK models - Meeting date: March 19, 2020",Supporting & Related Material,Report,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:09Z,,0,0,0900006484738234 EPA-HQ-OAR-2004-0074-0238,EPA,EPA-HQ-OAR-2004-0074,Agenda for TAP Meeting,Supporting & Related Material,Meeting Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:09Z,,0,0,0900006484738235 EPA-HQ-OAR-2004-0074-0249,EPA,EPA-HQ-OAR-2004-0074,Clewell - Model Uncertainty Analysis,Supporting & Related Material,Meeting Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:15Z,,0,0,0900006484738de0 EPA-HQ-OAR-2004-0074-0244,EPA,EPA-HQ-OAR-2004-0074,Final Report - Pharmacokinetic Evaluation of the Equivalency of Oral Routes of Manganese Exposure in F344 Rats,Supporting & Related Material,Report,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:13Z,,0,0,0900006484738a71 EPA-HQ-OAR-2004-0074-0248,EPA,EPA-HQ-OAR-2004-0074,Yoon - Rat Transporter Paper,Supporting & Related Material,Publication - Copyrighted Materials,2020-08-06T04:00:00Z,2020,8,,,2020-08-06T17:42:15Z,,0,0,0900006484738dde EPA-HQ-OAR-2004-0074-0234,EPA,EPA-HQ-OAR-2004-0074,Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models,Supporting & Related Material,Publication - Copyrighted Materials,2013-12-04T05:00:00Z,2013,12,,,2013-12-04T19:55:51Z,,0,0,090000648149c798 EPA-HQ-OAR-2004-0074-0235,EPA,EPA-HQ-OAR-2004-0074,Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development,Supporting & Related Material,Publication - Copyrighted Materials,2013-12-04T05:00:00Z,2013,12,,,2013-12-04T19:55:51Z,,0,0,090000648149c8a3 EPA-HQ-OAR-2004-0074-0227,EPA,EPA-HQ-OAR-2004-0074,Yoon Supplementary Data 1,Supporting & Related Material,Data,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:02Z,,0,0,090000648149c8a4 EPA-HQ-OAR-2004-0074-0223,EPA,EPA-HQ-OAR-2004-0074,Afton Chemical Letter EPA transmitting manganese PBPK models,Supporting & Related Material,Letter,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:02Z,,0,0,090000648149c732 EPA-HQ-OAR-2004-0074-0233,EPA,EPA-HQ-OAR-2004-0074,Response to the 10/31/2013 TAP Meeting from Hanmner,Supporting & Related Material,Letter,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:03Z,,0,0,090000648149cd2b EPA-HQ-OAR-2004-0074-0230,EPA,EPA-HQ-OAR-2004-0074,Yoon presentaton to TAP,Supporting & Related Material,Meeting Materials,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:03Z,,0,0,090000648149c8aa EPA-HQ-OAR-2004-0074-0228,EPA,EPA-HQ-OAR-2004-0074,Yoon Supplementary Data 2,Supporting & Related Material,Data,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:03Z,,0,0,090000648149c8a5 EPA-HQ-OAR-2004-0074-0229,EPA,EPA-HQ-OAR-2004-0074,Yoon Supplementary Data 3,Supporting & Related Material,Report,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:03Z,,0,0,090000648149c8a6 EPA-HQ-OAR-2004-0074-0224,EPA,EPA-HQ-OAR-2004-0074,Schroeter Presentation to TAP,Supporting & Related Material,Meeting Materials,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:02Z,,0,0,090000648149c79a EPA-HQ-OAR-2004-0074-0225,EPA,EPA-HQ-OAR-2004-0074,Schroeter Supplementary Data 1,Supporting & Related Material,Data,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:02Z,,0,0,090000648149c79f EPA-HQ-OAR-2004-0074-0226,EPA,EPA-HQ-OAR-2004-0074,Schroeter Supplementary Data 2,Supporting & Related Material,Data,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:02Z,,0,0,090000648149c7a0 EPA-HQ-OAR-2004-0074-0231,EPA,EPA-HQ-OAR-2004-0074,Agenda for Meeting of TAP,Supporting & Related Material,Meeting Materials,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:03Z,,0,0,090000648149c8ab EPA-HQ-OAR-2004-0074-0232,EPA,EPA-HQ-OAR-2004-0074,Report of the 10/31/2013 TAP Meeting,Supporting & Related Material,Report,2013-12-03T05:00:00Z,2013,12,,,2013-12-03T14:02:03Z,,0,0,090000648149c8ac EPA-HQ-OAR-2004-0074-0222,EPA,EPA-HQ-OAR-2004-0074,The Hamner Institute for Health Sciences Presentation on use of Physiologically-based pharmacokinetic (PBPK) modeling to reduce uncertainty in risk assessment: Example of manganese.,Supporting & Related Material,Report,2010-10-01T04:00:00Z,2010,10,,,2010-10-01T16:39:08Z,,0,0,0900006480b6489c EPA-HQ-OAR-2004-0074-0221,EPA,EPA-HQ-OAR-2004-0074,Afton Chemical Corporation letter describing proposed continuation of the Alternative Tier 2 reporting procedure to include development of the Mn PBPK models for humans,Supporting & Related Material,"Letter, Memorandum, Email",2009-08-19T04:00:00Z,2009,8,,,2009-08-19T17:38:56Z,,0,0,0900006480a0d174 EPA-HQ-OAR-2004-0074-0220,EPA,EPA-HQ-OAR-2004-0074,Model Code for the Manganese Physiologically-Based Pharmcokinetic Gestation and Lactation Rat Model,Supporting & Related Material,Data,2009-06-23T04:00:00Z,2009,6,,,2009-06-23T14:13:08Z,,0,0,09000064809d2e22 EPA-HQ-OAR-2004-0074-0219,EPA,EPA-HQ-OAR-2004-0074,EPA Memorandum Transmiting Comments on Review and Approval of the Manganese Physiologically-Based Pharmacokinetic Gestation and Lactation Rat Model,Supporting & Related Material,"Letter, Memorandum, Email",2009-06-19T04:00:00Z,2009,6,,,2009-06-19T20:00:05Z,,0,0,09000064809d2e23 EPA-HQ-OAR-2004-0074-0215,EPA,EPA-HQ-OAR-2004-0074,"Email from Dr. Jerry Roper, Afton Chemical, providing response to EPA's December 23, 2008 Comments on Manganese pharmacokinetic (PBPK) Gestation and Lactation Rat Model",Supporting & Related Material,"Letter, Memorandum, Email",2009-06-19T04:00:00Z,2009,6,,,2009-06-19T19:42:45Z,,0,0,09000064809d27c5 EPA-HQ-OAR-2004-0074-0216,EPA,EPA-HQ-OAR-2004-0074,"Afton Manuscript to be Submitted for Publication, Entitled, ""Evaluating Placental Transfer and Tissue Concentrations of Manganese in the Pregnant Rat and Fetuses after Inhaltion Exposures with a PBPK Model",Supporting & Related Material,Publication - Copyrighted Materials,2009-06-19T04:00:00Z,2009,6,,,2011-10-26T16:58:20Z,,0,0,09000064809d27c6 EPA-HQ-OAR-2004-0074-0217,EPA,EPA-HQ-OAR-2004-0074,"Afton Manuscript That Has Been Accepted for Publicaiton Entitled, ""Lactational Transfer of Manganese in Rats: Predicting Manganese Tissue Concentration in the Dam and Pups from Inhalation Exposure with a Pharmacokinetic Model",Supporting & Related Material,Publication - Copyrighted Materials,2009-06-19T04:00:00Z,2009,6,,,2011-10-26T17:04:17Z,,0,0,09000064809d2e1e EPA-HQ-OAR-2004-0074-0218,EPA,EPA-HQ-OAR-2004-0074,"Afton Report by Drs. Anderson and Yoon Entitled, Documentation of the Physiologically Based Pharmacokinetic Model for Manganese During Gestation and Lactation in the Rat (3/31/08)",Supporting & Related Material,Report,2009-06-19T04:00:00Z,2009,6,,,2009-06-19T19:53:01Z,,0,0,09000064809d2e21 EPA-HQ-OAR-2004-0074-0213,EPA,EPA-HQ-OAR-2004-0074,Agenda for 1/29/09 Meeting on Mn PBPK Models (Physiologically Based Pharmacokinetic/ Pharmacodynamic (PBPK/PD) Model),Supporting & Related Material,Meeting/Teleconference Materials,2009-02-09T05:00:00Z,2009,2,,,2009-02-09T13:06:54Z,,0,0,090000648084634c EPA-HQ-OAR-2004-0074-0214,EPA,EPA-HQ-OAR-2004-0074,Presentation by Dr. Jerry Roper at 1/29/09 Meeting,Supporting & Related Material,Meeting/Teleconference Materials,2009-02-09T05:00:00Z,2009,2,,,2009-02-09T13:07:01Z,,0,0,0900006480846364 EPA-HQ-OAR-2004-0074-0212,EPA,EPA-HQ-OAR-2004-0074,Presentation by Dr. Harvey Clewell at the 1/29/09 meeting,Supporting & Related Material,Meeting/Teleconference Materials,2009-02-05T05:00:00Z,2009,2,,,2009-02-05T15:01:06Z,,0,0,09000064808463cf EPA-HQ-OAR-2004-0074-0211,EPA,EPA-HQ-OAR-2004-0074,Presentation by Dr. Miyoung Yoon at 1/29/09 meeting,Supporting & Related Material,Meeting/Teleconference Materials,2009-02-05T05:00:00Z,2009,2,,,2009-02-05T15:01:00Z,,0,0,09000064808463c2 EPA-HQ-OAR-2004-0074-0210,EPA,EPA-HQ-OAR-2004-0074,Presentation by Dr. Andy Nong at 1/29/09 meeting,Supporting & Related Material,Meeting/Teleconference Materials,2009-02-05T05:00:00Z,2009,2,,,2009-02-05T15:00:56Z,,0,0,09000064808463ae EPA-HQ-OAR-2004-0074-0209,EPA,EPA-HQ-OAR-2004-0074,Presentation by Dr. Melvin Andersen during 1/29/09 meeting,Supporting & Related Material,Meeting/Teleconference Materials,2009-02-05T05:00:00Z,2009,2,,,2009-02-05T15:00:51Z,,0,0,0900006480846393 EPA-HQ-OAR-2004-0074-0208,EPA,EPA-HQ-OAR-2004-0074,Bibliography of Scientific Papers Published From the MMT Alternative Tier 2 (Stage 1) Test Program,Supporting & Related Material,,2009-02-05T05:00:00Z,2009,2,,,2009-02-05T15:00:46Z,,0,0,090000648084637f EPA-HQ-OAR-2004-0074-0197,EPA,EPA-HQ-OAR-2004-0074,Afton Transmittal Letter for Developmental Mn Physiologically-Based Pharmacokinetic (PBPK) Models (29 August 2008),Supporting & Related Material,"Letter, Memorandum, Email",2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:06:49Z,,0,0,09000064808210ec EPA-HQ-OAR-2004-0074-0204,EPA,EPA-HQ-OAR-2004-0074,USEPA Comments and Approval of Manganese (Mn) Pharmacokinetic (PBPK) Non-Human Primate Model,Supporting & Related Material,"Letter, Memorandum, Email",2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:07:19Z,,0,0,09000064808214d2 EPA-HQ-OAR-2004-0074-0205,EPA,EPA-HQ-OAR-2004-0074,USEPA Comments on Manganese (Mn) Physiologically Based Pharmacokinetic Modeling (PBPK) Gestation and Lactation Rat Model,Supporting & Related Material,"Letter, Memorandum, Email",2009-01-16T05:00:00Z,2009,1,,,2009-01-16T19:21:07Z,,0,0,09000064808213b7 EPA-HQ-OAR-2004-0074-0206,EPA,EPA-HQ-OAR-2004-0074,Afton Transmittal Letter Providing Additional Documentation on the Physiologically-Based Pharmacokinetic (PBPK) Model for Manganese in Non-Human Primates,Supporting & Related Material,"Letter, Memorandum, Email",2009-01-16T05:00:00Z,2009,1,,,2009-01-16T19:21:11Z,,0,0,09000064808213f6 EPA-HQ-OAR-2004-0074-0207,EPA,EPA-HQ-OAR-2004-0074,A Revised Manuscript on Manganese Physiologically-based Pharmacokinetic (PBPK) Model for Non-human Primates,Supporting & Related Material,Publication - Copyrighted Materials,2009-01-16T05:00:00Z,2009,1,,,2011-10-26T16:53:42Z,,0,0,090000648082142d EPA-HQ-OAR-2004-0074-0201,EPA,EPA-HQ-OAR-2004-0074,Files Containing Modeling Code for Manganese (Mn) Developmental Models,Supporting & Related Material,Data,2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:07:07Z,,0,0,0900006480821318 EPA-HQ-OAR-2004-0074-0199,EPA,EPA-HQ-OAR-2004-0074,A Hamner Institute Presentation entitled: Manganese Developmental Model for Rats,Supporting & Related Material,Study,2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:07:00Z,,0,0,09000064808211cd EPA-HQ-OAR-2004-0074-0200,EPA,EPA-HQ-OAR-2004-0074,Technical Advisory Panel (TAP) Comments on the Developmental Models and Dr. Andersen's Response,Supporting & Related Material,Report,2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:07:04Z,,0,0,09000064808212c2 EPA-HQ-OAR-2004-0074-0198,EPA,EPA-HQ-OAR-2004-0074,Manganese Developmental Physiologically-Based Pharmacokinetic (PBPK) Model Report,Supporting & Related Material,Report,2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:06:53Z,,0,0,0900006480821117 EPA-HQ-OAR-2004-0074-0202,EPA,EPA-HQ-OAR-2004-0074,"Afton Report addressing EPA's May 11, 2001 comments on manganese (Mn) Pharmacokinetic (PBPK) Non-human primate model (27 October 2008)",Supporting & Related Material,Report,2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:07:11Z,,0,0,0900006480821456 EPA-HQ-OAR-2004-0074-0203,EPA,EPA-HQ-OAR-2004-0074,Model Code for the Manganese (Mn) Pharmacokinetic (PBPK) Non-Human Primate Model,Supporting & Related Material,Physical Item,2009-01-16T05:00:00Z,2009,1,,,2009-01-16T18:07:15Z,,0,0,09000064808214a1 EPA-HQ-OAR-2004-0074-0195,EPA,EPA-HQ-OAR-2004-0074,EPA Comments on Draft Manganese Physiologically-Based Pharamcokinetic Non-human Primate Model,Supporting & Related Material,"Letter, Memorandum, Email",2008-09-23T04:00:00Z,2008,9,,,2008-09-23T13:39:27Z,,0,0,09000064806f0fe9 EPA-HQ-OAR-2004-0074-0191,EPA,EPA-HQ-OAR-2004-0074,Afton Cover Letter transmitting draft PBPK model describing manganese in non-human primates,Supporting & Related Material,"Letter, Memorandum, Email",2008-09-23T04:00:00Z,2008,9,,,2008-09-23T13:39:22Z,,0,0,09000064806f0f4e EPA-HQ-OAR-2004-0074-0192,EPA,EPA-HQ-OAR-2004-0074,A manuscript describing the draft manganese PBPK models for rat and non-human primates,Supporting & Related Material,Report,2008-09-23T04:00:00Z,2008,9,,,2008-09-23T13:39:23Z,,0,0,09000064806f0f77 EPA-HQ-OAR-2004-0074-0193,EPA,EPA-HQ-OAR-2004-0074,The model code in acslXtreme,Supporting & Related Material,Data,2008-09-23T04:00:00Z,2008,9,,,2008-09-23T13:39:24Z,,0,0,09000064806f0fab EPA-HQ-OAR-2004-0074-0196,EPA,EPA-HQ-OAR-2004-0074,Hamner's transmittal letter to Afton (21 April 2008),Supporting & Related Material,"Letter, Memorandum, Email",2008-09-23T04:00:00Z,2008,9,,,2008-09-23T15:08:19Z,,0,0,09000064806f0fd7 EPA-HQ-OAR-2004-0074-0194,EPA,EPA-HQ-OAR-2004-0074,Afton Technical Advisory Panel Comments on the draft model,Supporting & Related Material,Report,2008-09-23T04:00:00Z,2008,9,,,2008-09-23T13:39:25Z,,0,0,09000064806f0fbd EPA-HQ-OAR-2004-0074-0190,EPA,EPA-HQ-OAR-2004-0074,Technical Advisory Plan (TAP) Presentation Slides on Manganese Physiologically Based Pharmacokinetic (PBPK) model in the rat,Supporting & Related Material,Publication - Copyrighted Materials,2008-06-16T04:00:00Z,2008,6,,,2011-10-26T16:49:17Z,,0,0,0900006480614f86 EPA-HQ-OAR-2004-0074-0188,EPA,EPA-HQ-OAR-2004-0074,Technical Advisory Plan (TAP) Presentation Slides on Manganese Physiologically Based Pharmacokinetic (PBPK) Model in the rat,Supporting & Related Material,Report,2008-06-10T04:00:00Z,2008,6,,,2008-06-10T16:20:20Z,,0,0,0900006480614fca EPA-HQ-OAR-2004-0074-0189,EPA,EPA-HQ-OAR-2004-0074,"Presentation Slides presented by the Hamner Institute for Health Sciences to Afton and USEPA Staff during March 11, 2008 Scientific Meeting",Supporting & Related Material,Report,2008-06-10T04:00:00Z,2008,6,,,2008-06-10T16:20:20Z,,0,0,0900006480615033 EPA-HQ-OAR-2004-0074-0187,EPA,EPA-HQ-OAR-2004-0074,Technical Advisory Plan (TAP) Presentation Slides on Manganese Physiologically Based Pharmacokinetic (PBPK) Model in the rats and monkeys,Supporting & Related Material,Report,2008-06-10T04:00:00Z,2008,6,,,2008-06-10T16:20:19Z,,0,0,0900006480614f63 EPA-HQ-OAR-2004-0074-0184,EPA,EPA-HQ-OAR-2004-0074,EPA Comments on Draft Manganese Physiologically-Based Pharmacokinetic Rat Model,Supporting & Related Material,"Letter, Memorandum, Email",2008-06-09T04:00:00Z,2008,6,,,2008-06-09T15:46:22Z,,0,0,09000064806150a8 EPA-HQ-OAR-2004-0074-0186,EPA,EPA-HQ-OAR-2004-0074,Technical Advisory Plan (TAP) Presentation Slides on Manganese Physiologically Based Pharmacokinetic (PBPK) Model in the rat,Supporting & Related Material,Report,2008-06-09T04:00:00Z,2008,6,,,2008-06-09T18:03:50Z,,0,0,0900006480614f9f EPA-HQ-OAR-2004-0074-0182,EPA,EPA-HQ-OAR-2004-0074,"Presentation Slides presented by the Hamner Institute for Health Sciences to Afton and EPA Staff during March 11, 2008 Scientific Meeting",Supporting & Related Material,Report,2008-06-09T04:00:00Z,2008,6,,,2008-06-09T15:46:20Z,,0,0,090000648061505e EPA-HQ-OAR-2004-0074-0181,EPA,EPA-HQ-OAR-2004-0074,Summary Report of the ManganesePhysiologically Based Pharmacokinetic (PBPK) Model by the Hamner Institutes for Health Sciences for the Afton Chemical Corporation,Supporting & Related Material,Report,2008-06-09T04:00:00Z,2008,6,,,2008-06-09T15:46:19Z,,0,0,0900006480614f18 EPA-HQ-OAR-2004-0074-0185,EPA,EPA-HQ-OAR-2004-0074,Technical Advisory Panel (TAP) Comments and Dr. Melvin Andersen's Response for Manganese Physiologically Based Pharmacokinetic (PBPK) Model in the rat,Supporting & Related Material,"Letter, Memorandum, Email",2008-06-09T04:00:00Z,2008,6,,,2008-06-09T18:03:49Z,,0,0,0900006480614f45 EPA-HQ-OAR-2004-0074-0183,EPA,EPA-HQ-OAR-2004-0074,"Presentation Slides presented by the Hamner Institute for Health Sciences to Afton and EPA Staff during March 11, 2008 Scientific Meeting",Supporting & Related Material,Report,2008-06-09T04:00:00Z,2008,6,,,2008-06-09T15:46:21Z,,0,0,090000648061507c EPA-HQ-OAR-2004-0074-0178,EPA,EPA-HQ-OAR-2004-0074,Afton Cover Letter transmitting Draft Manganese Physiologically-Based Pharmacokinetic (PBPK) model for the rat,Supporting & Related Material,"Letter, Memorandum, Email",2008-06-06T04:00:00Z,2008,6,,,2008-06-06T19:58:41Z,,0,0,0900006480614e6c EPA-HQ-OAR-2004-0074-0180,EPA,EPA-HQ-OAR-2004-0074,Manuscript describing the Draft Manganese model in the rat,Supporting & Related Material,Publication - Copyrighted Materials,2008-06-06T04:00:00Z,2008,6,,,2011-10-26T16:39:38Z,,0,0,0900006480614ed9 EPA-HQ-OAR-2004-0074-0179,EPA,EPA-HQ-OAR-2004-0074,Letter from The Hamner Institutes for Health Sciences to the Afton Chemical Corporation transmitting the Draft Manganese Physiologically Based Pharmacokinetic (PBPK) Model for the rat,Supporting & Related Material,"Letter, Memorandum, Email",2008-06-06T04:00:00Z,2008,6,,,2008-06-06T19:58:42Z,,0,0,0900006480614e97 EPA-HQ-OAR-2004-0074-0177,EPA,EPA-HQ-OAR-2004-0074,Poster on manganese PBPK models presented by Andy Nong of The Hamner Institutes for Health Sciences at the International Congress of Toxicology,Supporting & Related Material,Fact/Data Sheet,2007-10-10T04:00:00Z,2007,10,,,2007-10-10T19:55:10Z,,0,0,09000064802fe517 EPA-HQ-OAR-2004-0074-0176,EPA,EPA-HQ-OAR-2004-0074,Update and progress report on manganese PBPK models (10/9/2007),Supporting & Related Material,"Letter, Memorandum, Email",2007-10-10T04:00:00Z,2007,10,,,2007-10-10T19:55:09Z,,0,0,09000064802fe507 EPA-HQ-OAR-2004-0074-0175,EPA,EPA-HQ-OAR-2004-0074,Manganese (Mn) Technical Advisory Panel Report #2,Supporting & Related Material,Report,2007-04-20T04:00:00Z,2007,4,,,2007-04-20T17:19:32Z,,0,0,0900006480229663 EPA-HQ-OAR-2004-0074-0174,EPA,EPA-HQ-OAR-2004-0074,EPA Memorandum: Draft Manganese Physiologically-Based Pharmacokinetic Rat Models,Supporting & Related Material,"Letter, Memorandum, Email",2007-04-20T04:00:00Z,2007,4,,,2007-04-20T17:19:31Z,,0,0,0900006480229651 EPA-HQ-OAR-2004-0074-0173,EPA,EPA-HQ-OAR-2004-0074,Afton Progress Report,Supporting & Related Material,"Letter, Memorandum, Email",2007-04-20T04:00:00Z,2007,4,,,2007-04-20T17:19:29Z,,0,0,090000648022963f EPA-HQ-OAR-2004-0074-0172,EPA,EPA-HQ-OAR-2004-0074,Technical Advisory Panel Comments,Supporting & Related Material,"Letter, Memorandum, Email",2007-03-12T04:00:00Z,2007,3,,,2007-03-12T12:30:46Z,,0,0,090000648020a966 EPA-HQ-OAR-2004-0074-0171,EPA,EPA-HQ-OAR-2004-0074,Draft Report: PK Modeling of Mn in Brain,Supporting & Related Material,Report,2007-02-26T05:00:00Z,2007,2,,,2007-02-26T20:14:15Z,,0,0,090000648020a937 EPA-HQ-OAR-2004-0074-0167,EPA,EPA-HQ-OAR-2004-0074,Draft Manganese Olfactory Model,Supporting & Related Material,Report,2007-02-23T05:00:00Z,2007,2,,,2007-02-23T17:47:12Z,,0,0,090000648020a930 EPA-HQ-OAR-2004-0074-0168,EPA,EPA-HQ-OAR-2004-0074,Draft Report: PBPK Modeling for Mn in Rats,Supporting & Related Material,Report,2007-02-23T05:00:00Z,2007,2,,,2007-02-23T17:47:13Z,,0,0,090000648020a949 EPA-HQ-OAR-2004-0074-0165,EPA,EPA-HQ-OAR-2004-0074,Transmittal Letter from Afton to EPA regarding first set of draft manganese PBPK models,Supporting & Related Material,"Letter, Memorandum, Email",2007-02-23T05:00:00Z,2007,2,,,2007-02-23T17:46:48Z,,0,0,090000648020a91e EPA-HQ-OAR-2004-0074-0166,EPA,EPA-HQ-OAR-2004-0074,Transmittal Letter from CIIT to Afton,Supporting & Related Material,"Letter, Memorandum, Email",2007-02-23T05:00:00Z,2007,2,,,2007-02-23T17:47:08Z,,0,0,090000648020a925 EPA-HQ-OAR-2004-0074-0169,EPA,EPA-HQ-OAR-2004-0074,Draft Report: Modeling Dose Route Differences in Hepatic Mn Extraction,Supporting & Related Material,Report,2007-02-23T05:00:00Z,2007,2,,,2007-02-23T17:47:14Z,,0,0,090000648020a955 EPA-HQ-OAR-2004-0074-0170,EPA,EPA-HQ-OAR-2004-0074,Draft Report: Compartmental PK Modeling of Manganese Kinetics,Supporting & Related Material,Report,2007-02-23T05:00:00Z,2007,2,,,2007-02-23T17:47:17Z,,0,0,090000648020a95c EPA-HQ-OAR-2004-0074-0163,EPA,EPA-HQ-OAR-2004-0074,Email transmitting ORD comments on 10/31/2005 Draft Final MMT Emission Characterization Report to Afton,Supporting & Related Material,"Letter, Memorandum, Email",2006-04-03T04:00:00Z,2006,4,,,2006-09-02T15:38:30Z,,0,0,0900006480146c0f EPA-HQ-OAR-2004-0074-0164,EPA,EPA-HQ-OAR-2004-0074,"Final Report entitled, ""A Report of the Results of Alternative Tier 2 Testing for the Characterization of Particulate from Vehicles Using the Gasoline Additive MMT in the Fuel",Supporting & Related Material,Report,2006-04-03T04:00:00Z,2006,4,,,2006-09-02T15:38:30Z,,0,0,0900006480146c49